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What causes drug-induced nail disease? Drugs can damage the nail matrix (the hidden part of the nail unit under the cuticle), the nail bed (the skin beneath the nail plate [the visible part of the nail]), periungual tissue (tissue situated around the nail), or blood vessels feeding the nail or nails.. In general, the higher the dose of the drug, the more likely it is to cause nail disease.

Nail abnormalities is reported as a side effect among people who take Metformin (metformin hydrochloride), especially for people who are male, 60+ old, also take Lyrica, and have Psoriasis. The phase IV clinical study analyzes which people have Nail abnormalities when taking Metformin, including time on the drug, (if applicable) gender, age, co ...

276 Possible Metformin-Induced Toe Nails Disorder . Figure 1. Toe nails disorder during the second use of met- formin. were normal (see Figure 2). 3. Discussion . About 6 months after the start of metformin 0.5 g three times per day, this 60-year-old patients experienced toe nails disorder including discoloration and thickening.

Drug-induced nail disorders are uncommon adverse reactions that can occur as a result of drugs. ... This disorder can cause the separation of the nail into two sections, causing pain due to an ...

Infective cause, dis- ... This article reports an interesting and a rare case of metformin induced nail disorder in a middle aged female with type 2 diabetes. The patient had been receiving ...

Acquired pincer nail deformity has been reported most f requently with ill-fitting shoes and in association with medications, but other disorders can be associated such as subungual exostosis, psoriasis, onychomycosis, tumors of the nail apparatus and systemic diseases such as lupus erythematosus, Kawasaki disease, Diabetes, renal disorders ...

A large number of drugs may be responsible for the development of nail changes, including cancer chemotherapeutic agents and retinoids, however, only a few classes of drugs are consistently associated with nail symptoms. Drug-induced nail abnormalities result from toxicity to the matrix, the nail be …

Drug-induced nail changes usually involve several or all 20 nails and appear in temporal correlation with drug intake. Some nail changes are asymptomatic and only cause cosmetic problems, while others cause pain and discomfort and impair manual activities or deambulation.

Drug-induced nail abnormalities can present with a wide variety of clinical manifestations that are often dose-related and that disappear after drug withdrawal. Some nail changes are asymptomatic and only cause cosmetic problems, whereas others cause pain and discomfort and impair manual activities …

The aim of this article was to report a case of toe nails disorder associated with metformin use in an elderly patient with type2diabetes. Two years ago, after receiving metformin 0.5 g three times daily for 6 months, a 60-year-old Chinese man found his ten toe nails gradually thickened and yellowed (especially two thumbs). The symptoms improved and recovered after metformin discontinuance.

Although many nail disorders have been associated with drug intake, most reports are anecdotal. Most nail changes caused by drugs are the outcome of acute toxicity to the nail epithelia, but other mechanisms can be involved. Nail symptoms vary depending on which nail structure is affected.

For people with diabetes, having nail fungus can increase the risk of a bacterial skin infection surrounding the nail, which can be serious and may require antibiotic use. For this reason, it is important that people with diabetes get treated for their nail infections. 1. What causes nail fungus?

This article reports an interesting and a rare case of metformin induced nail disorder in a middle aged female with type 2 diabetes. The patient had been receiving metformin one 1500mg daily from ...

Nail changes caused by drugs are often dose-related, appear in temporal relation with drug intake and usually disappear after its withdrawal. They present with a wide variety of symptoms, depending on the part of the nail apparatus that has been damaged.

The exact mechanism of metformin induced yellowish discolouration is not known. Only a single case report has been published till far regarding metformin induced toe nail disorder.6 Metformin is one of the important drugs used in the management of type 2 diabetes mellitus, so this ADR should be kept in mind while prescribing metformin.

Nail fungus: People with diabetes are also more likely to develop nail fungus. This is because high blood sugar levels can create a warm, moist environment that is ideal for the growth of fungus. Fungal infections can cause thickening, crumbling, and discolored nails. Potential Causes of Nail Issues in Diabetes:

Metformin effects were uniform on the HR scale for all variables, but heterogeneous by age on the absolute (RD) scale, with diabetes incidence rate reduced in the metformin group compared with the placebo group in participants aged 25–44 years (–2·22 cases [95% CI –3·61 to –0·83] per 100 person-years) but not in participants aged 60 ...

Nail disorder is a known ADR of metformin. The patients could totally recover after discontinuation of metformin without any treatment. Infective cause, disease and other concomitant medications can be ruled out. The probability of an adverse drug reaction (ADR), as assessed using the Naranjo ADR probability scale, in this case was 5 (probable ...

The aim of this article was to report a case of toe nails disorder associated with metformin use in an elderly patient with type2diabetes. Two years ago, after receiving metformin 0.5 g three times daily for 6 months, a 60-year-old Chinese man found his ten toe nails gradually thickened and yellowed (especially two thumbs). The symptoms improved and recovered after metformin discontinuance.