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This page lists all known medications that could potentially lead to 'Melanonychia' as a side effect. It's important to note that mild side effects are quite common with medications.

Among the iatrogenic causes of melanonychia, the most common are phototherapy, X-ray exposure, and medication (antimalarial therapy, hydroxyurea, busulphan, bleomycin, doxorubicin, cyclophosphamide, 5-fluorouracil). These are most frequently associated with transverse melanonychia .

Melanonychia can be associated with different types of fungal, bacterial, and viral infections.‌ Inflammation. Melanonychia can be caused by inflammatory skin diseases that affect your nails.

Melanonychia is a nail condition in which melanin is present in the nail plate. It has many possible causes and can sometimes be malignant, so an accurate diagnosis is vital. ... Drugs: Drugs ...

drugs, are the principal cause of drug-induced melanonychia.4 Other drugs that have been implicated include antiretrovirals (lami-vudine, zidovudine), antimalarials (mepacrine, amodiaquine, chlo-roquine), metals (arsenic, thallium, mercury, gold salts), psoralens with UVA, and radiotherapy. The pigmentation usually partially or completely fades ...

Melanonychia affects up to 20% of Japanese people. White-skinned people are less commonly affected. Melanonychia can also be associated with genetic disorders, injury, medications, nutritional deficiency, endocrine disease, connective tissue disease, inflammatory skin disease, a local tumour, or nail infection. What causes melanonychia?

List of drugs relevant to our case and their association with melanonychia (Litt’s Drug Eruption Manual, 22nd edition) ... Drug-induced melanonychia is hypothesized to be due to melanocytic activation combined with increased melanin synthesis and deposition . Chemotherapy medications can be associated with a variety of nail changes including ...

One or several nails may be affected, but usually not all nails. The causative drugs are primarily chemotherapeutic agents, antibiotics, and antimalarials. Cancer chemotherapeutic agents may result in melanonychia and leukonychia 1-2 months from the start of treatment. Doxorubicin can produce leukonychia and melanonychia within the same nail.

Melanonychia has been reported to be due to alcaptonuria, hemosiderosis, hyperbilirubinemia, and porphyria [2, 10]. Iatrogenic Causes — Iatrogenic causes of melanocytic activation include medications (especially chemotherapeutic agents) [17–19], phototherapy, X-ray exposure, and electron beam therapy (Figure 3, Table 2) .

The list of common drugs causing melanonychia and their features are listed in Table 2.[7 11] Chemotherapeutic drugs are the most common agents. Intermittent administration of chemotherapy can result in alternating bands of pigmentation. Table 2: Drug-induced melanonychia.

In conclusion, Melanonychia, characterized by dark vertical lines on the nails, is a condition with various potential causes, including trauma, medications, skin conditions, and vitamin deficiencies. The key is to identify the underlying cause and seek appropriate treatment.

Melanonychia is brown, gray, or black discoloration of the nail plate that can be caused by many conditions, ranging from benign to malignant. 1 Careful evaluation is needed to rule out melanoma and other malignant causes of nail discoloration. Treatment varies based on the underlying cause. 1 This article describes the etiology, symptoms, and treatment of melanonychia and how to distinguish ...

drugs causing melanonychia and their features are listed in . Table 2. [7,1 1] Chemotherapeutic drugs are the most common . agents. [7] Intermittent administration of chemotherapy can .

Dr. Hinshaw will lecture on melanonychia at the ODAC Dermatology Conference to be held January 17-20, 2025, in Orlando. How commonly do you see melanonychia in your nail clinic? Melanonychia is a very common presentation to the nail clinic and dermatology in general. Patients often notice it, become alarmed by it, and seek our care.

Melanonychia tends to persist, except when it is related to medication – in which case it fades following withdrawal of the medication. Nail matrix melanoma tends to have a poor prognosis. Tseng YT, Liang CW, Liau JY, Chang K, Tseng YH, Chen JS, et al. Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at ...

“Melanonychia” describes a brown/brown-black pigmented longitudinal or transverse band on the fingernail/toenail in response to reactive and neoplastic disorders and as a side effect of chemotherapeutic and systemic treatments.1 Hydroxyurea (HU), a cytostatic drug used in managing myeloproliferative disorders, can cause mucocutaneous adverse reactions, including hyperpigmentation ...

Common causes of longitudinal melanonychia due to melanocytic activation include inflammatory and traumatic nail disorders, drugs (chemotherapy, azidothymidine, antimalarials, PUVA therapy) (Fig. 450-11), and systemic diseases (acquired immunodeficiency syndrome [Chapter 399]; Addison's disease [Chapter 234]).

Non-Medication Treatments for Melanonychia Laser Therapy. Laser therapy uses concentrated light beams to target and treat affected areas, promoting healing and reducing discoloration. It is a non-invasive procedure. This treatment is often used for melanonychia caused by benign pigmented lesions or fungal infections. It is considered when ...

Among drugs able to induce melanonychia the most common causes are chemotherapeutic agents. A long list of cancer chemotherapeutic agents may activate clusters of nail matrix melanocytes inducing melanin production, giving rise to the development of melanonychia in multiple longitudinal or transverse bands.