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The principles of how chaperones function together in a network to optimize histone delivery and storage are beginning to emerge 5, and a key feature seems to be that multiple chaperones can ...

Histone chaperones build a network of escort functions. Recent crystallographic studies have provided new insights into the relationships between histone chaperones and their cargo, the histones ...

Histone chaperones participate in the biogenesis, transportation, and deposition of histones. They contribute to processes impacted by nucleosomes including DNA replication, transcription, and epigenetic inheritance. In this issue, Carraro et al.1 reveal an interconnected chaperone network and a surprising function of histone chaperone DAXX in de novo deposition of H3.3K9me3.

Histone chaperones are key actors during histone metabolism. Here we classify known histone chaperones and discuss how they build a network to escort histone proteins. Molecular interactions with histones and their potential specificity or redundancy are also discussed in light of chaperone structural properties. The multiplicity of histone ...

Histone chaperones- “the guardian of genome stability and epigenetic information” controls the chromatin accessibility by escorting the nucleosomal and non-nucleosomal histones as well as their variants. ... Histone Chaperone Networks Shaping Chromatin Function. Nat. Rev. Mol. Cel Biol 18, 141–158. 10.1038/nrm.2016.159 [PMC free article ...

Histone chaperone networks, including Hsc70 and chromatin assembly factor 1(CAF1), have been shown to guide H3.1 positioning and function . For this function, p53 appears to down-regulate nuclear phosphatidic acid (PA) levels, likely via its transcriptional activity, and exclude EZH2 from the H3.1 interactome . HspA8 is highly overexpressed in ...

We identified DNAJC9 as a co-chaperone of MCM2 and TONSL that can substitute for ASF1. Our structure-function characterization reveals that DNAJC9 has both heat shock co-chaperone and histone chaperone functionalities, integrating ATP-dependent protein remodeling enzymes into the histone chaperone network to safeguard histone H3-H4 dimer integrity.

Histone chaperone network. The integration of histone chaperone functions to support histone dynamics across various cellular processes. Canonical histones. Core histone subtypes (H3.1, H3.2, H4, H2A and H2B) that are expressed in S phase of the cell cycle and mainly incorporated into nucleosomes in a DNA replication-dependent manner.

To uncover the potential network of histone chaperones and their co-factors, Carraro et al. 1 employ triple SILAC-based quantitative mass spectrometry and compare the interactomes of several commonly known chaperones and their mutant counterparts defective of histone binding. Interestingly, most of the analyzed histone chaperones (ASF1a, ASF1b, DAXX, DNAJC9, HJURP, sNASP, MCM2, and TONSL ...

Whether distinct histone chaperone pathways control cell fate and whether they function using related mechanisms remain unclear. To address this, we performed a screen to assess the requirement of diverse histone chaperones in the self-renewal of hematopoietic stem and progenitor cells. Remarkably, all candidates were required to maintain cell ...

Histone chaperones can also participate in the distribution of histone variants, thereby defining distinct chromatin landscapes of importance for genome function, stability, and cell identity. ... chaperones and their histone partners, focusing on histone H3 and its variants. We then place them into an escort network that distributes these ...

With the evolution of histone variants, a network of functionally specific histone chaperones has emerged. Molecular details of the determinants of chaperone specificity for different histone variants are only slowly being resolved. ... Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization ...

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Network of major histone chaperones Histone chaperones facilitate the transport of histones from the ribosome to the nucleus and aid in their subsequent deposition onto chromatin. This figure was created with BioRender.com. Previews Molecular Cell 83, April 6, 2023 1025 ll. 2. Serra-Cardona, A., and Zhang, Z. (2018).

In order to find new members of the histone chaperone network and with an elegantly designed proteomic screen, Hammond et al. (2021) identify DNAJC9 collaborating with the well-characterized histone chaperones MCM2 and TONSL. They solve the crystal structure of the C-terminal histone-binding domain (HBD) of DNAJC9 in complex with the histone H3 ...

Histone chaperones participate in the biogenesis, transportation, and deposition of histones. They contribute to processes impacted by nucleosomes including DNA replication, transcription, and epigenetic inheritance. In this issue, Carraro et al.¹ reveal an interconnected chaperone networ …

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Carraro et al. charted the histone H3–H4 chaperone network, revealing co-chaperone relationships involved in nucleosome assembly and unveiling that histone chaperone DAXX promotes lysine 9 tri-methylation of new histone H3.3 prior to deposition onto DNA. With its functionality, DAXX provides a molecular mechanism for de novo heterochromatin assembly.