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Golgi apparatus - Models, Protein, Movement: The way in which proteins and lipids move from the cis face to the trans face is a matter of debate, and today there exist multiple models, with quite different perceptions of the Golgi apparatus, competing to explain this movement. The vesicular transport model, for example, stems from initial studies that identified vesicles in association with ...

Three models of protein transport within the Golgi complex. (A) Cisternal maturation model. Secretory cargo is transported in an anterograde direction along with cisternae maturation from cis-face to trans-face of the Golgi complex. Golgi resident proteins are transported in retrograde through COPI vesicles. (B) Rapid partitioning model. The Golgi stacks are distributed into two sub-domains ...

Anterograde vesicular transport between stable compartments. Secretory cargoes travel from the ER to the intermediate compartment (IC) and cis -Golgi in dissociative carriers. Golgi compartments are stable and biochemically distinct. Secretory cargoes move across the stack by means of COPI vesicles that bud from one compartment and fuse with the next, whereas resident Golgi proteins stay in ...

(A) The cisternal maturation model of protein movement through the Golgi. As a new cis cisterna is formed it traverses the Golgi stack, changing as it matures by accumulating medial, then trans ...

Abstract The Golgi complex is a central processing compartment in the secretory pathway of eukaryotic cells. This essential compartment processes more than 30% of the proteins encoded by the human genome, yet we still do not fully understand how the Golgi is assembled and how proteins pass through it. Recent advances in our understanding of the molecular basis for protein transport through the ...

The diffusion model based on permanent inter-cisternal connections cannot explain the existence of lipid, ionic and protein gradients across the Golgi stacks. In contrast, the kiss-and-run model has the potential to explain most of the experimental observations.

Proteins can move through the Golgi via the vesicular transport model or the cisternal maturation model. Additionally, proteins are sorted for transport to their final destinations, utilizing anterograde and retrograde transport mechanisms, ensuring proper cellular function.

Two models compete to explain the way proteins transit through the Golgi, a cellular organelle consisting of stacked membrane-bound compartments (cisternae) and responsible for protein maturation and sorting. The cisternal maturation model proposes that cisternae created de novo move through the stack, carrying their content with them. The vesicular transport model views cisternae as static ...

The mechanism by which proteins move through the Golgi apparatus is an area of controversy among cell biologists, with two competing models for protein movement: the vesicular transport model and the cisternal maturation model.

The Golgi apparatus is essential for cellular function, directing protein traffic within cells. It modifies, sorts, and packages proteins for delivery to their designated destinations, ensuring smooth cellular processes. Understanding its mechanisms provides insights into cell biology and disease pathology. Structure of the Golgi Apparatus The Golgi apparatus, a central hub in the cell’s ...

Here, we analyse the data related to the mechanisms of endoplasmic reticulum-to-Golgi and intra-Golgi transport from the point of view of the main models of intracellular transport; namely: the vesicular model, the diffusion model, the compartment maturation–progression model, and the kiss-and-run model.

What Happens To Proteins As They Move Through the Golgi? Figure 1: The Golgi apparatus modifies and sorts proteins for transport throughout the cell.

The Golgi complex is the central sorting and processing station of the secretory pathway, ensuring that cargo proteins, which are synthesized in the endoplasmic reticulum, are properly glycosylated and packaged into carriers for transport to their final destinations. Two recent studies highlight the fact that properties of membrane lipids play key roles in Golgi structural organization and ...

The function of the Golgi has long been recognized to critically depend on vesicular transport from, to, and within its cisternae, involving constant membrane fission and fusion. These processes are mediated by Arf GTPases and coat proteins, and ...

The Golgi apparatus plays an important role in sorting proteins and modifying them after translation, using specific transport processes that are vital for its function.

Putative role of COPI-coated vesicles and tubules according to vesicular transport and cisternal maturation models for intra-Golgi transport. According to vesicular transport model, cisternae are static. Anterograde transport may be mediated by COPI-coated vesicles and tubular cisternal connections. Another type of COPI-coated vesicles mediates retrograde transport (i.e., the retrieval of ...

Two models of Golgi network maturation can be found in cell biology textbooks: in the ‘traditional model’, vesicles containing cargo proteins travel from sac to sac on a production line, being ...

Download scientific diagram | Three models of protein transport within the Golgi complex. (A) Cisternal maturation model. Secretory cargo is transported in an anterograde direction along with ...

Rab32 is a small GTPase and molecular switch implicated in vesicular trafficking. Rab32 is also an A-Kinase Anchoring Protein (AKAP), which anchors cAMP-dependent Protein Kinase (PKA) to specific subcellular locations and specifies PKA phosphorylation of nearby substrates. Surprisingly, we found that a form of Rab32 deficient in PKA binding (Rab32 L188P) relocalized away from the Golgi ...