mavii

Splinter haemorrhage is a short longitudinal line within the nail due to capillary bleeding and grows out with the nail. Drugs that cause splinter haemorrhage, and subungual haemorrhage, include: Anticoagulants and antiplatelet agents; Taxanes; ... A brownish discolouration of the nail bed — which can be due to antimalarial drugs ...

Nonmelanic pigmentation occurs when the nail matrix extracts the drug and stores it in the nail, or the drug deposits in the nail or subungual area. The nail may turn blue, brown, or gray, depending on the drug, and the color will grow out as the nail does. 1,20,21; Irritant or allergic reactions. Topical agents sometimes cause nail changes ...

Drug-induced nail disorders are uncommon adverse reactions that can occur as a result of drugs, with nail abnormalities being due to acute damage to the nail unit leading to symptoms associated with the corresponding nail structure. ... and this can sometimes cause nail loss. ... which can manifest as light brown or black vertical or horizontal ...

Brown discoloration of the nails can occur due to external factors. There may be no internal abnormality that leads to the change in nail color and if the external factor is removed, the nails should return to a normal color with time. ... Drugs. A number of drugs can cause a brown discoloration of the nails. It is usually not specific to the ...

Nail changes are often associated with treatment with systemic medications. Nail pigment change secondary to drugs can be brown, black, yellow, white, or blue in color. The pigment distribution can be longitudinal, diffuse, or may only affect the lunula. Pigment may be separated by bands of normal pink color.

Drugs may cause other nail problems, such as melanonychia striata (brown or black pigmented lines) and onycholysis. Different drugs lead to discoloration of the nail, which usually gets better after the drug is stopped and the nail grows out. Chemotherapy drugs may cause a darkening (hyperpigmentation) of the nail plate.

Chemotherapy agents like doxorubicin and cyclophosphamide can cause a darkening or browning of the nails. This discoloration is thought to be a result of the drugs' effects on the nail matrix, where the nail is formed. Certain antibiotics, such as tetracyclines and minocycline, can also cause nail discoloration. These medications can lead to a ...

Drug-induced nail abnormalities can present with a wide variety of clinical manifestations that are often dose-related and that disappear after drug withdrawal. Some nail changes are asymptomatic and only cause cosmetic problems, whereas others cause pain and discomfort and impair manual activities or deambulation. New side effects have been recently observed with different groups of ...

1. Discoloration: Some medications can cause your nails to change color. For example, certain antibiotics like tetracycline can result in yellow or brown discoloration of the nails. 2. Brittle Nails: Certain medications, such as isotretinoin used for acne treatment, can make your nails brittle and prone to breakage. 3.

These drugs can cause nail fragility, dryness, and brittleness. In some cases, retinoids may also lead to nail discoloration or peeling. ... Medications can cause nails to become yellow, brown, or even greenish. 2. Brittle or Fragile Nails: If your nails become weak, brittle, or easily breakable, it could be a sign of drug-induced nail damage. 3.

The type of melanonychia varies with the causative drug; nail bed pigmentation, transverse bands, and longitudinal melanonychia can be seen either alone or together. Transverse melanonychia, ... Hematoma is the most common cause of nail brown-black pigmentation. It can be either acute (following single heavy trauma) or chronic (repeated, micro ...

Drug-induced nail disorders are uncommon adverse reactions that can occur as a result of drugs. ... and this can sometimes cause nail loss. ... which can manifest as light brown or black vertical ...

Most drug-induced nail disorders resolve after discontinuation of the drug, although complete resolution sometimes takes several years. Drugs appear to induce nail disorders through a variety of mechanisms. Some drugs affect the nail matrix epithelium, the nail bed or the nail folds. Some alter nail colour. Other drugs induce photosensitivity.

Drug-induced nail changes usually involve several or all 20 nails and appear in temporal correlation with drug intake. Some nail changes are asymptomatic and cause only cosmetic problems, whereas others cause pain and discomfort and impair manual activities or ambulation. Drug-induced nail abnormalities are usually transitory and disappear with ...

Drug-induced changes of nails have been observed with a variety of different medical drugs, both topical and systemic. ... Melanonychia is a brownish or blackish nail plate coloration either of the whole plate or in a streaked pattern. In the differential diagnosis, melanocytic nevi, subungual melanoma, and subungual hematoma should be excluded ...

A large number of drugs may be responsible for the development of nail changes, including cancer chemotherapeutic agents and retinoids, however, only a few classes of drugs are consistently associated with nail symptoms. Drug-induced nail abnormalities result from toxicity to the matrix, the nail be …

Discussion. Melanonychia is described as the brown to black pigmentation of the nail. It may be due to stimulation and hyperplasia of nail matrix melanocytes, invasion of nail by melanin producing pathogens, subungual haemorrhage and also due to drugs [1–5].We present a brief report on a patient with non Hodgkin lymphoma - follicular type who developed diffuse blackish discoloration of nails ...

The pathogenesis of drug-induced nail changes is not always readily explained. In most cases, nail alterations are the result of a toxic effect of the drug on the nail epithelia. Clinical manifestations depend on the anatomic constituent of the nail that has been damaged (Table 1). The same drug can cause the simultaneous presence of different ...

Drug-induced nail changes usually involve several or all 20 nails and appear in temporal correlation with drug intake. Some nail changes are asymptomatic and only cause cosmetic problems, while others cause pain and discomfort and impair manual activities or deambulation. Drug-induced nail abnormalities are usually transitory and disappear with ...