When platelets become hyperactive and prone to aggregation due to cigarette smoking, they can contribute to the formation of blood clots that can block the flow of blood to the brain. Some clots, known as ischemic strokes, can cause irreversible damage to brain tissue and lead to a range of neurological impairments, from paralysis and speech ...
Objective— Whether tobacco smoking causally affects white and red blood cells and thrombocyte counts is unknown. Using a Mendelian randomization approach, we tested the hypothesis that smoking causes increases in these blood cell indices. Approach and Results— We included 104 607 white Danes aged 20 to 100 years from the Copenhagen General Population Study with information on blood cell ...
The effect of smoking on platelet count is still controversial. We performed a cross section-al study to compare the platelet count and platelet parameters in Thai police who are smokers and non-smokers. A total of 30 Thai police in Bangkok were included in this study. Of the 30 police, there are 5 non-smokers and 25 smokers.
Background Smoking is associated with an increased risk of myocardial infarction and sudden death. Platelet activation and thrombosis at sites of vessel stenosis and injury or plaque disruption play a crucial role in these acute coronary events. Thus, the aim of this study was to determine whether cigarette smoking acutely increases platelet thrombus formation on an injured arterial surface at ...
experimental study that platelet increases can be observed in rats exposed to smoking (5). We de-tected no significant difference in platelet count and platelet parameters between smokers and non-smokers. The null effect of smoking on platelets is similar to that reported by Blann and colleagues (6). According to the observations in our subjects,
Platelet activity measured by the PFA-100 is been increased significantly after cigarette smoking (P = .004). Shorter CTs were determined after smoking in all patients with and without baseline persistent platelet activity, and 4 more participants became aspirin nonresponder (P = .004).
Purpose: Smoking is a significant risk factor of cardiac ischaemia. Changes in platelet count, morphology and platelet activation enhance the risk. Material and methods: The objective of the study was to assess platelet parameters in smoking healthy subjects with reference to sex. In the group of women, 27% were smokers, in the group of men--49%.
Background: Smoking is a potent risk factor for coronary artery disease; however, prior studies describe increased platelet inhibition with clopidogrel among smokers, and some studies report improved outcomes among smokers, a finding described as the smoker’s paradox. This study assessed the relationship between platelet reactivity and clinical outcomes after percutaneous coronary ...
Elevated platelet aggregation induced by passive smoking may cause an increase in the risk of cardiac ischemic disease even by 34%. The importance of platelet count per se in cardiovascular disease is indicated by several studies which suggest that increased platelet counts frequently attend hyper ...
A high platelet count can indicate an underlying condition. However, it can also occur spontaneously, meaning that it happens on its own and not as an effect of another illness. ... A wide range of diseases and conditions can cause high platelets, including: anemia, such as from iron deficiency or hemolytic anemia; ... Smoking is associated ...
Some studies indicate that the platelet count increased with smoking, 3 while some studies claim that the platelet count decreases in chronic smokers and that an increase in the duration of smoking was associated with a significant reduction in the platelet counts. 9 It has been demonstrated that the levels of thrombopoietin were increased in ...
Finally, several studies have shown that white cell count and differential leukocyte percentages and markers of platelet activity are impaired due to cigarette smoking 11, 12. Passive smoking plays a central pathogenetic role in lipid peroxidation and atherosclerotic plaque formation 13 and has been associated with increased risk of coronary ...
are more sensitive to smoking than men. Platelets in male smokers are less sensitive to smoking – the study showed no significant changes in the parameters. Key words: platelet count, parameters of thrombocytopoiesis, platelet activation, smoking. Introduction Tobacco smoking is one of the major factors accelerating atherosclerosis [1].
The MPV and the platelet count were highest and their inverse correlation was strongest in the atherosclerotic smokers (r = 0.54, P < 0.05) when compared with the nonsmoking and non-atherosclerotic groups. A 10% decrease of MPV was found in 8 smoking subjects in the atherosclerotic group, who successfully discontinued smoking (P < 0.05).
Can stress cause high platelets? Yes, stress can indeed cause high platelets, a condition known as reactive thrombocytosis or secondary thrombocytosis. Disclaimer: This article is intended for informational purposes only and is specifically targeted towards medical students. It is not intended to be a substitute for informed professional ...
An increased propensity for platelet aggregate formation and blood clotting in people exposed to cigarette smoke has been documented in a number of studies dating back to the 1960s. 72,73,74,75,76 ...
In this issue of Arteriosclerosis, Thrombosis, and Vascular Biology, Barua et al 8 strengthen the argument for a direct functional effect of CSE in thrombosis by demonstrating abnormal fibrin clot dynamics and structure in plasma from individuals exposed to acute CSE. Whereas baseline fibrin clot dynamics and structure in platelet-rich and platelet-poor plasma in nonsmokers and smokers is ...
Platelets are essential mediators of inflammation and thrombosis. Chronic obstructive pulmonary disease (COPD) is a heterogeneous multisystem disease, causing significant morbidity and mortality worldwide. Recent evidence suggests that the lung is an important organ for platelet biogenesis. Cigarette smoking has been shown to induce platelet aggregation and decrease the capacity of ...
