Toll-Like Receptors: Sensors that Detect Infection
Fortunately, the immune response functions as a defense mechanism ... The discovery of microbial-sensing proteins called Toll-like receptors is helping to answer these questions and transform ...
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Toll-like receptors and phagosome maturation
In a recent Perspective in Nature Immunology 1, Blander and Medzhitov explored the function of Toll-like receptor (TLR) signaling in controlling the maturation of phagosomes in macrophages and ...
Novel Drugs Targeting Toll-like Receptors for Antiviral Therapy
EMCV: Encephalomyocarditis virus; HCMV: Human CMV: MCMV: Mouse CMV; MMTV: Mouse mammary tumor virus; pDC: Plasmacytoid dendritic cell; PTV: Punta Toro virus; SARS-CoV ...
Complex interactions between nucleic acid sensors and enzymes in immune cells explained
Adenosine deaminase 2 (ADA2) has been identified as a regulator of toll-like receptor 9 (TLR9 ... is revealed to function as an intracellular DNA-binding protein that controls TLR9 activation ...